Senior Director MIDD lead
Standort: Upper Providence, Home Worker - USA
Datum: Mar 9 2026
Company OverviewAt GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. GSK enters 2026 with strong momentum, building on 2025 growth and advancing a robust pipeline. We expect key regulatory milestones, including new approvals and expanded indications, supported by 15 pivotal trials. By uniting science, technology, and talent, we remain committed to getting ahead of disease together. The Clinical Pharmacology and Quantitative Medicine (CPQM) group at GSK is a newly established organization dedicated to becoming a Centre of Excellence in Model-Informed Drug Development (MIDD). CPQM uniquely integrates expertise in clinical pharmacology, digital medicine, translational imaging, and mechanistic and systems modeling. Under the strategic leadership of the MIDD Head, the MIDD team drives strategy and innovation in clinical pharmacology and quantitative medicine. This function is essential for advancing GSK’s MIDD capabilities, efficiency, and impact, with a strong focus on respiratory, immunology, inflammation, hepatology, neurodegeneration, and emerging areas within the Respiratory, Immunology & Inflammation Research Unit (RIIRU). The MIDD team is responsible for leading the development and execution of comprehensive therapeutic or sub-therapeutic area MIDD evidence strategies across RIIRU. Job Purpose
The MIDD Lead is a scientific and strategic leader applying modelling and simulation to inform critical drug development decisions. The role leads MIDD evidence strategies and serves as the technical expert for a therapeutic or sub‑therapeutic area within RIIRU. It drives advanced modelling approaches integrating disease‑level data and novel digital and imaging endpoints to support asset‑ and mechanism‑level decisions. The role combines pharmacometrics, systems pharmacology, biostatistics, and data science to optimize dosing, trial design, regulatory strategy, and go/no‑go decisions. It advances both established M&S methodologies and emerging technologies, including AI/ML and SciML. A key objective is delivering robust, transparent MIDD evidence to de‑ris
k and accelerate programs. The role requires strong cross‑functional collaboration across CPQM, RIIRU, and GSK. Key Responsibilities:Own end‑to‑end MIDD evidence strategies for a therapeutic or sub‑therapeutic area, guiding data prioritisation, integration, quality assessment, and application of advanced modelling to drive scientific, program, and business decisions. Act as the MIDD technical authority, leading M&S plans, analyses, and reports, coaching internal and external analysts, and supporting regulatory interactions involving quantitative evidence. Lead the delivery of robust, transparent MIDD evidence to de‑risk and accelerate programs, advising on optimized internal and regulatory MIDD strategies. Drive consistent use of established M&S methodologies (e.g., MBMA, disease progression modelling) and integrate emerging technologies (AI/ML, SciML) through standards, training, and best practices. Build strong internal and external networks across CPMS, QSP, AI/ML, digital, biomarkers, and academia to shape future methodologies and strengthen GSK’s scientific and regulatory presence. Why you? Basic Qualifications: PhD or PharmD in pharmacometrics, Clinical pharmacology, Physiological Pharmacokinetic and Pharmacodynamic based modelling or related quantitative disciplines QSP. Minimum of 7 years experience in quantitative clinical pharmacology / pharmacometrics in an industry environment. Minimum of 7 years experience in quantitative clinical pharmacology / pharmacometrics in an industry environment.
Preferred Qualifications:Postdoctoral experience preferred in pharmacometrics, Clinical pharmacology, Physiological Pharmacokinetic and Pharmacodynamic based modelling or related quantitative disciplines QSP. A strong understanding of relevant regulatory and ICH guidelines across major markets related to the design of clinical studies and drug development strategy with particular emphasis on the role of MIDD. An advanced understanding of appropriate regulatory and ICH guidelines across major markets in the design of clinical studies and drug development strategy with particular emphasis on the role of MIDD. Ability to quickly attain the therapeutic or sub-therapeutic area literacy sufficient to implement and communicate the MIDD strategy to clinical experts.
The US annual base salary for new hires in this position ranges from $202,500 to $337,500. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.
If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - usrecruitment.adjustments@gsk.com. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/
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